Search results for: Research

Advanced genome sequencing identifies new genetic links for leukodystrophy

During the last decade, incredible improvements in the speed, accuracy and cost-effectiveness of whole-genome sequencing have accelerated our understanding of genetic disorders. An international Leukodystrophy Study Group, including researchers with Baylor Scott & White Research Institute (BSWRI), has used these next-generation sequencing methods to reveal the genetic abnormalities in a cohort of 71 persistently undiagnosed individuals with suspected leukodystrophy. Leukodystrophies are rare genetic disorders that disrupt the myelin sheath, which forms the white matter in the brain.

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Improved criteria for diagnosing osteomyelitis

Prevalence of the bone infection osteomyelitis (OM) has increased along with the increased prevalence of diabetes. It is estimated that OM is a complication for at least 10% of diabetic foot ulcers and approximately 50% of severe cases. Delays in the diagnosis and treatment of OM can lead to poor patient outcomes and high healthcare costs. However, an accurate and timely diagnosis of OM is hindered by a lack of clear guidelines for histopathological assessment. Therefore, researchers from Baylor Scott & White Research Institute, along with their collaborators, have created a new diagnostic framework for OM.

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New research from BSWRI offers model to identify progression mechanism of, and therapies for, α-Synucleinopathic neurodegenerative disorders

Baylor Scott & White Research Institute researcher Erxi Wu, Ph.D. recently co-authored a paper published in Nature Communications, demonstrating the successful creation of a mouse model of pure autonomic dysfunction caused by α-Syn pathology. Researchers believe this model could help establish mechanistic links between the transmission of pathological α-Syn and the cardinal features of autonomic dysfunction in α-Synucleinopathy.

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