Cardiogenic shock represents a dynamic set of conditions, presentation profiles and pathophysiologic mechanisms whose mortality has not changed in more than 20 years. While almost 75 percent is due to predominant left ventricular failure, a quarter is due to something else, such as a rupture or tamponade, right ventricle shock or acute severe mitral regurgitation.

Heart failure and diabetes are closely intertwined.  Diabetes affects not only coronary artery blood flow, but also the myocardium. Patients with type 2 diabetes are at risk of heart failure due to intrinsic myocardial disease, resulting in increased myocardial hypertrophy, fibrosis and stiffness. This can also lead to a form of heart failure described in literature as diabetic cardiomyopathy.