In 2021, more than 3,000 patients received a heart transplant in the United States and an additional 3,500 patients were awaiting transplantation. Expansion of the donor pool from a variety of factors has led to an increase in the number of heart transplants today compared to a decade ago. However, acute rejection, including acute cellular and antibody-mediated, continues to be a major source of morbidity and death among heart transplant recipients.