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June 2020

Advanced genome sequencing identifies new genetic links for leukodystrophy

Baylor Scott & White Research Institute|Research

During the last decade, incredible improvements in the speed, accuracy and cost-effectiveness of whole-genome sequencing have accelerated our understanding of genetic disorders. An international Leukodystrophy Study Group, including researchers with Baylor Scott & White Research Institute (BSWRI), has used these next-generation sequencing methods to reveal the genetic abnormalities in a cohort of 71 persistently undiagnosed individuals with suspected leukodystrophy. Leukodystrophies are rare genetic disorders that disrupt the myelin sheath, which forms the white matter in the brain.

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May 2020

Improved criteria for diagnosing osteomyelitis

Baylor Scott & White Medical Center - Temple|Baylor Scott & White Research Institute|Research

Prevalence of the bone infection osteomyelitis (OM) has increased along with the increased prevalence of diabetes. It is estimated that OM is a complication for at least 10% of diabetic foot ulcers and approximately 50% of severe cases. Delays in the diagnosis and treatment of OM can lead to poor patient outcomes and high healthcare costs. However, an accurate and timely diagnosis of OM is hindered by a lack of clear guidelines for histopathological assessment. Therefore, researchers from Baylor Scott & White Research Institute, along with their collaborators, have created a new diagnostic framework for OM.

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May 2020

COVID-19 forces transplant programs to reassess their approach to transplant allocation decisions

Baylor University Medical Center|COVID-19|Transplant Services

As the COVID-19 (SARS-CoV-2) pandemic has taken hold in the United States, transplant programs have had to prepare to make critical decisions during a time of severely constrained resources. A transition must be made from the traditional “justice versus utility” approach in organ allocation to a more nuanced allocation scheme based on ethical values that drive decisions in times of absolute scarcity. The goal of this new mind-set is to help guide programs in deciding which patients to transplant, which donors to accept, how to minimize risk and how to ensure the best utilization of transplant team members.

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