Hepatic encephalopathy (HE), which manifests as decreased brain function, is a common, debilitating condition seen in patients with liver disease. The symptoms can range from attention deficits to coma and are largely reversible. The healthcare burden of HE is profound: HE is the leading cause of 3-month readmission for patients with cirrhosis in North America and is associated with increased mortality. Researchers at Baylor Scott & White Research Institute have summarized the latest insights into the pathophysiology and treatment of HE in a recent issue of Nutrition in Clinical Practice.